Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.
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A formulation yielding clear and transparent appearance and the one not cracking when observed for 24 h was selected for further studies. All versions This eumlgel Views 81 81 Downloads 52 52 Data volume Evaluation of emulgel 7 – 11 Optimization: Invited for research articles. The particle size of 1: Jatinder Pal Singh Chawla.
Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.
Herein, no further evaluation and animal studies were done to assess the implications of the formulation in vivo. Dr Ashok Kumar Verma. Search in Google Scholar. Hence, developing formulation strategies for aceclofenac is particularly imperative 12.
On the contrary, in the placebo group inflammation persisted till the 4th h and later showed a decline which was statistically insignificant compared to the treated groups, which reinstates the efficacy of aceclofenac, lack of any activity attributed to excipients and effective delivery of the drug. The animal studies were conducted in the animal house, under appropriate care and precautions.
Hence, a microemulsion of Aceclofenac was formulated, which was later formed into an emulgel. Terbinafine hydrochloride, CarbapolAntifungal activity, Film formation, Emulgel formulation.
Thus, the microemulsion base improved the solubility of the drug and the emulgel formulation enhanced the delivery in a sustained manner. Hence, we addressed the issues of previously published studies, presenting a novel research.
The optimized formulation was subjected to gelling, resulting in formulation of an emulgel.
In view of the foregoing, we attempted to formulate a microemulsion based emulgel of aceclofenac and tested the efficacy of the evaluuation in animal models of inflammation. The study yields novel insights into the formulation strategies for designing a water soluble novel drug delivery system of an anti-inflammatory, low-solubility drug aceclofenac.
Polysorbate 80, isopropyl myristate, was procured from Molychem Mumbai, India and Loba chemie pvt limited, Mumbai, Indiarespectively.
No allergic symptoms like inflammation, redness, irritation appeared on rats up to 24 h. In this investigation, a microemulsion-based emulgel of aceclofenac was successfully formulated, which lead to improved solubility and drug release of aceclofenac. The oxiconazole used in treatment of various fungal infections formlation as cutaneous and subcutaneous diseases like acne and psoriasis.
Compared with ointments and creams, gelsprovide a better feel are greaseless and easily washable. Based on the results of this study, pseudo ternary phase diagram was plotted using the Andd software, to calculate the surfactant and co-surfactant ratio Smix.
The present work is to develop Clindamycin emulgel adaptable topical drug delivery systems which provide protection against oxidation, fast absorption, prolonged release and enables reduction in dose and evaluate the emulgel using an formulatioon topical drug candidate of Clindamycin by suitable method with its release.
Additionally, a gel formulation aids in faster drug release in comparison to other semisolids 2.
Preparation and evaluation of aceclofenac topical microemulsion. An effective anti-inflammatory drug is purported to act via both the pathways, thus mitigating inflammation. Hence, the topical route would be one of the ideal alternatives to enhance local delivery, bypassing these side effects. The aim of present study was to emhlgel an emulgel formulation of clindamycin phosphate using Carbopol or HPMC as a gelling agent. This is indicative of the improved solubility brought about by emklgel microemulsion formulation.
Clindamycin emulgel, Formulation, Evaluation. Skin irritation test patch test 7 – The aceclofenac microemulsion was transparent yellow colored solution with a pH of 5. All the prepared emulgels showed satisfactory physicochemical properties like color, homogeneity, consistency, spreadability, and pH value. Recent expansions in an emergent novel drug delivery technology: The total duration of this study was approximately 5 months considering conceptualization to completion of animal studies.
Microemulsion containing 15 mg of aceclofenac was evenly applied onto the surface formulatkon dialysis membrane along with formultion suspension in water for comparison.
Ointments, Creams and Gels. It has a better tolerability profile as well as a better analgesic activity in comparison with diclofenac. The anti-inflammatory activity was numerically more in voltaren emulgel as compared to aceclofenac emulgel.
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The dialysis membrane was attached between the donor and the receptor chamber of diffusion cell. The aim of present work was to develop and evaluate Oxiconazole emulgel with controlled release.
In an earlier kf conducted by Pani et al.