By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.
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Carriers show the potential to absorb the liquid medication.
Pharmaceutical applications of liquisolid technique
In conclusion, Liquisolid technology was effective for improving dissolution rate as well as bio-availability in practically water insoluble drugs with non-volatile solvents. The concept behind this approach is adsorption and absorption both. High R values 30 to 60 evidence better uniform distribution of the drug in the carrier material Tayel et al.
As these days there are many drugs in the market with poor solubility which leads to poor dissolution and bioavailability, so solubility is becoming rate limiting factor in the development of new drugs.
This solution is shaken with shaker for specific period of time than liqquisolid is filtered and analyzed teechnique UV spectrophotometer. This study suggested that Avicel had more liquid retention potential due to the high specification area of Avicel 1.
Therefore, this is due to their significantly increased wetting properties and increased surface area technqiue drug available for dissolution. It should be compatible with having ability to solubilise the drug. Finally, this study reported that MCC PH is a suitable carrier for preparing liquisolid systems in terms of having acceptable flowability, friability, hardness, and dissolution profile.
Liauisolid of some commercial grades of microcrystalline cellulose on flowability, compressibility and dissolution profile of piroxicam liquisolid compacts. Further decrease in the ratio of microcrystalline cellulose: Hence, the liquisolid technology allows the transformation of liquid systems into solid drug delivery systems. Different concentrations of non-volatile solvents are taken and the drug is dissolved.
Announcements Editorial Board Indexing Contact. Coating material should be with yechnique adsorptive property so that when used for coating the carrier particles can absorb the excessive non volatile solvent layer over the carrier ,iquisolid and can give dry solid appearance to the saturated carrier particles having liquid external layer of non volatile solvent.
The results also showed that wet granulation had a marked impact on reducing dissolution release rate of propranolol HCl from liquisolid formulations Javadzadeh et al.
In this study, different formulations of liquisolid tfchnique using different co-solvents non-volatile solvents were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated.
Liquisolid technique has been classified on the basis of liquid active moieties, viz. According to this equation, stagnant diffusion layer thickness is h, and formed by the dissolving liquid around tefhnique drug particles. In the third step suitable superdisintegrants like sodium starch Glycolate or Crosspovidone is added in the prepared mixture techjique continuous shaking in a mortar.
Liquisolid preparations may be hampered by their poor and erratic flow and compaction properties. The height of the funnel was adjusted in such a way that the tip of the funnel just touches the apex of the heap of the powder. According techniqie this method the conversion of water insoluble drug into dry looking, liqiisolid adherent, free flowing and acceptably compressible powder by incorporating into suitable non volatile solvents, carrier material and coating materials.
National Center for Biotechnology InformationU. Enhancement of dissolution rate of piroxicam using liquisolid compacts. Due to this the liquid layer gets converted in the solid layer and this gives the dry, non adherent, free flowing powder particles.
Dissolution test was carried out at two different pH, 1. In a study by Yousef Javadzadeh et al. Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt. The height and diameter of the powder cone was measured and angle of repose was calculated.
Need of liquisolid technique: By decreasing the ratio of microcrystalline cellulose to silica from 20 to 10, an improvement in dissolution rate was observed.
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Pharmaceutical applications of liquisolid technique
Hence due to above reasons liquisolid technique is most efficient and novel approach for solubility enhancement. Alkali metal salts of acidic drugs like penicillin and strong acid salts of basic drugs like atropine are more water soluble than parent drugs.
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Enhancement of solubility and dissolution rate of frusemide through liquisolid technique. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.